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Effects of Epidural Local Anesthetics on Propofol Induction

C

China Medical University

Status and phase

Completed
Phase 4

Conditions

Thoracic Epidural Anesthesia
General Anesthesia
Propofol Target-controlled Infusion

Treatments

Drug: Ropivacaine
Drug: Lidocaine
Drug: Normal Saline
Drug: Bupivacaine

Study type

Interventional

Funder types

Other

Identifiers

NCT02000973
20131012

Details and patient eligibility

About

The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.

Enrollment

80 patients

Sex

All

Ages

45 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Surgery for thoracotomies, BMI: 18-25 Kg/m2, American Society of Anesthesiologists(ASA) classification I or II.

Exclusion criteria

liver or kidney disease, alcohol dependence, take sedative recently, contraindications for epidural anesthesia.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

80 participants in 4 patient groups, including a placebo group

Normal saline
Placebo Comparator group
Description:
General anesthesia combined with thoracic epidural 0.9% normal saline 8ml
Treatment:
Drug: Normal Saline
Lidocaine
Experimental group
Description:
General anesthesia combined with thoracic epidural 1% lidocaine 8ml
Treatment:
Drug: Lidocaine
Bupivacaine
Experimental group
Description:
General anesthesia combined with thoracic epidural 0.25% bupivacaine 8ml
Treatment:
Drug: Bupivacaine
Ropivacaine
Experimental group
Description:
General anesthesia combined with thoracic epidural 0.3% ropivacaine 8ml
Treatment:
Drug: Ropivacaine

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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