Effects of Epidural Local Anesthetics on Propofol Induction

China Medical University

Status and phase: Completed; Phase 4

Conditions: Thoracic Epidural Anesthesia; General Anesthesia; Propofol Target-controlled Infusion

Treatments: Drug: Ropivacaine; Drug: Lidocaine; Drug: Normal Saline; Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02000973

20131012

Details and patient eligibility

About

The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.

Enrollment: 80 patients

Sex: All

Ages: 45 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Surgery for thoracotomies, BMI: 18-25 Kg/m2, American Society of Anesthesiologists(ASA) classification I or II.

Exclusion criteria

liver or kidney disease, alcohol dependence, take sedative recently, contraindications for epidural anesthesia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 4 patient groups, including a placebo group

Normal saline

Placebo Comparator group

Description:

General anesthesia combined with thoracic epidural 0.9% normal saline 8ml

Treatment:

Drug: Normal Saline

Lidocaine

Experimental group

Description:

General anesthesia combined with thoracic epidural 1% lidocaine 8ml

Treatment:

Drug: Lidocaine

Bupivacaine

Experimental group

Description:

General anesthesia combined with thoracic epidural 0.25% bupivacaine 8ml

Treatment:

Drug: Bupivacaine

Ropivacaine

Experimental group

Description:

General anesthesia combined with thoracic epidural 0.3% ropivacaine 8ml

Treatment:

Drug: Ropivacaine