Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men (PECS)

University of British Columbia

Status: Completed

Conditions: Amino Acids Metabolism; Extracellular Matrix; Skeletal Muscle; Dietary Supplements; Exercise

Treatments: Dietary Supplement: Collagen Peptide; Dietary Supplement: Maltodextrin Placebo; Dietary Supplement: Essential Amino Acid

Study type: Interventional

Funder types: Other

Identifiers

NCT04596553

H20-00943

Details and patient eligibility

About

The purpose of this study is to assess which amino acids are affecting acute muscle collagen synthesis in response to supplementation and exercise.

Full description

This is a double-blinded, randomized controlled, parallel design study, with 3 treatment groups (placebo, collagen peptide, and essential amino acid). The study will involve 3 visits: a baseline testing/familiarization session, and 2 exercise trials which will include muscle biopsies, blood draws, and the infusion of a tracer isotope in order to measure muscle protein synthesis.

Enrollment: 17 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Can fluently read and write in English
• Male
• 18 - 35 years

Exclusion criteria

• Diabetes, cardiovascular disease, or current pharmaceutical therapy
• Medical conditions impacting ability to undertake strenuous physical activity
• Lower body resistance training in the previous 6 months
• BMI > 30
• Currently smoking with cigarettes
• Allergy to any study supplements
• Currently taking any protein, amino acid, or collagen supplement
• Participate in greater than 2 hours of weekly vigorous exercise

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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17 participants in 3 patient groups, including a placebo group

Essential Amino Acid

Active Comparator group

Description:

Participants will consume 1 dose of: 15 g crystalline essential amino acid supplement (Pure Encapsulation Essential Aminos 180) + 80 ml (48 mg) Vitamin C (Ribena Blackcurrant) + 250 ml water

Treatment:

Dietary Supplement: Essential Amino Acid

Collagen Peptide

Active Comparator group

Description:

Participants will consume 1 dose of: 15g collagen peptide (Gelita TENDOFORTE) + 80 ml (48 mg) Vitamin C (Ribena Blackcurrant) + 250 ml water

Treatment:

Dietary Supplement: Collagen Peptide

Maltodextrin Placebo

Placebo Comparator group

Description:

Participants will consume 1 dose of:15 g maltodextrin (Canadian Protein Maltodextrin) + 80 ml (48 mg) Vitamin C (Ribena Blackcurrant) + 250 ml water

Treatment:

Dietary Supplement: Maltodextrin Placebo