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Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia

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Mass General Brigham

Status

Completed

Conditions

Schizophrenia

Treatments

Drug: eszopiclone
Drug: placebo

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT00833547
Sepracor051

Details and patient eligibility

About

This study will determine whether eszopiclone will normalize sleep patterns and restore sleep-dependent enhancement of motor skill learning in patients with schizophrenia. The investigators will compare subjects taking a placebo to those taking 3 mg of eszopiclone with regard to: sleep architecture and sleep latency as measured by actigraphy and polysomnography and sleep-dependent motor skill learning.

Enrollment

25 patients

Sex

All

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Clinically stable outpatients with DSM-IV diagnoses of Schizophrenia

Exclusion criteria

  • History of neurologic or psychiatric disease other than schizophrenia
  • Substance abuse or dependence within the past six months
  • Other chronic medical conditions that affect sleep
  • Pregnancy/breast feeding
  • Hepatic impairment
  • Treatment with metabolic inhibitors or inducers

Trial design

25 participants in 2 patient groups, including a placebo group

Eszopiclone
Experimental group
Description:
3mg of eszopiclone on two consecutive nights
Treatment:
Drug: eszopiclone
placebo
Placebo Comparator group
Description:
placebo capsule that looks identical to eszopiclone capsule on two consecutive nights
Treatment:
Drug: placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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