Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia

Mass General Brigham

Status: Completed

Conditions: Schizophrenia

Treatments: Drug: eszopiclone; Drug: placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00833547

Sepracor051

Details and patient eligibility

About

This study will determine whether eszopiclone will normalize sleep patterns and restore sleep-dependent enhancement of motor skill learning in patients with schizophrenia. The investigators will compare subjects taking a placebo to those taking 3 mg of eszopiclone with regard to: sleep architecture and sleep latency as measured by actigraphy and polysomnography and sleep-dependent motor skill learning.

Enrollment: 25 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinically stable outpatients with DSM-IV diagnoses of Schizophrenia

Exclusion criteria

• History of neurologic or psychiatric disease other than schizophrenia
• Substance abuse or dependence within the past six months
• Other chronic medical conditions that affect sleep
• Pregnancy/breast feeding
• Hepatic impairment
• Treatment with metabolic inhibitors or inducers

Trial design

25 participants in 2 patient groups, including a placebo group

Eszopiclone

Experimental group

Description:

3mg of eszopiclone on two consecutive nights

Treatment:

Drug: eszopiclone

placebo

Placebo Comparator group

Description:

placebo capsule that looks identical to eszopiclone capsule on two consecutive nights

Treatment:

Drug: placebo