Effects of Exercise and 5-HTP on Cortisol Levels

Benedictine University

Status: Unknown

Conditions: Plasma Cortisol

Treatments: Dietary Supplement: 5-HTP; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02187341

Ben-0614b

Details and patient eligibility

About

It has been shown that 5-HTP stimulates cortisol levels in plasma and saliva. Similarly, it has been shown that intense exercise stimulates an increase in plasma and salivary cortisol levels. The purpose of this study is to examine the combined effects of 5-HTP + intense exercise on plasma and salivary cortisol levels.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men and women, not taking medication known to alter glucocorticoid metabolism

Exclusion criteria

• Diabetes
• Obesity
• Hypertension
• Coronary artery disease
• Psychiatric disorders
• Any disease preventing them from participating in intense exercise
• Subjects taking medication known to interfere with glucocorticoid metabolism will be excluded

Trial design

12 participants in 2 patient groups, including a placebo group

5-HTP

Experimental group

Description:

200 mg 5-HTP capsule will be ingested 2h prior to reporting to the laboratory.

Treatment:

Dietary Supplement: 5-HTP

Placebo

Placebo Comparator group

Description:

For these visit subjects will ingest placebo (Sugar pill) capsule 2 hours before reporting to the laboratory.

Treatment:

Dietary Supplement: Placebo