Effects of Exercise Interventions in Frail Middle-aged and Older Adults

Taipei Veterans General Hospital

Status: Enrolling

Conditions: Frailty

Treatments: Device: exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT05279625

2021-10-014BCF

Details and patient eligibility

About

This study aimed to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and mental functions.

Full description

Exercise has been suggested as a possible lifestyle intervention for improving physical and cognitive performance. Various training options depending on various physical circumstances will be presented. However, the ideal exercise protocol for frail middle-aged and older adults had the greater benefits remain unknown. In general, 3-6 months of frequent exercise can enhance physical and cognitive outcome.

The investigators conduct this multiple arm, prospective study to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and cognitive functions. This study designed to recruit 200 older adults with frailty. All the older adults will receive exercise training using either elastic band, dumbbells, machines, treadmill, cycling for 6 months. Outcome measures including a systematic evaluation for frail older persons using comprehensive geriatric assessment, as well as the assessments of physical and cognitive functions before and after interventions.

Enrollment: 200 estimated patients

Sex: All

Ages: 50 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged above 50 years old with frailty syndrome

Exclusion criteria

• Acute illnesses, such as unstable cardiac dysrhythmia, sepsis, or unstable vital signs
• Physical or Cognitive issues that make it difficult for the patients to participate in our program

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 4 patient groups

Interval exercise training

Experimental group

Description:

Interval exercise training using either elastic band, dumbbells, treadmill, cycling for 6 months

Treatment:

Device: exercise training

continuous exercise training

Experimental group

Description:

continuous exercise training using either elastic band, dumbbells, treadmill, cycling for 6 months

Treatment:

Device: exercise training

machine-assisted exercise training

Experimental group

Description:

machine-assisted exercise training for 6 months

Treatment:

Device: exercise training

traditional rehabilitation

Active Comparator group

Description:

traditional rehabilitation for 6 months

Treatment:

Device: exercise training