Effects of Exercise on Functional Ability in People With Dementia in Nursing Homes:a Cluster Randomised Controlled Trial (LEDEN)

Toulouse University Hospital

Status: Completed

Conditions: Alzheimer Disease; Dementia

Treatments: Other: Exercise; Other: Social Activity

Study type: Interventional

Funder types: Other

Identifiers

NCT02444078

RC31/14/7292

2014-A01713-44 (Other Identifier)

Details and patient eligibility

About

This is a cluster randomised controlled trial composed of two research arms: exercise training group (experimental group) and a social activity group (control group).

Full description

The recruitment process will be made only in NHs (Nursing Home) where the staff will have voluntarily accepted to participate in the study. We estimated to recruit 140 PWD (person with dementia) from around six-to-eight NHs (i.e., in average a minimum of 18 and a maximum of 24 PWD per NH). NHs constitute the unit of randomisation; NHs will be randomised to study groups using a 1:1 ratio (it means that all the participants living in a particular NH will participate in either the exercise training or the social activity). The randomisation will be stratified by the prevalence of dementia among NH residents; this stratification will provide homogeneity across research's arms, increasing thus the comparability among groups and producing then reliable results. Randomisation will be done by a statistician not involved in the LEDEN study. Allocation concealment will be ensured by the use opaque sealed envelopes. The randomisation list will be kept in a electronic, password-locked file matching the name of participants to their research identification number and their group allocation. Given the nature of the LEDEN intervention (exercise training, i.e., a behavioural intervention) and since the main outcome measure, i.e., participants' ability in executing ADLs, of the the study requires that the outcome assessor knows how participants cope in their daily life, LEDEN is a unblinded study

Enrollment: 140 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed diagnosis of Alzheimer's disease, vascular or mixed dementia according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV);
• MMSE ≤ 20 (out of 30);
• living in one of the participating NHs for at least 3 months at the moment of baseline measurements (this time period will allow NH staff to have a good knowledge about the patient and about recent changes in his/her health status);
• to be able of walking at least 4 meters (with walking devices if needed but without human assistance);
• to be able to rise from a chair without help or with minimal human assistance.

Exclusion criteria

• Mild dementia, illustrated by a MMSE > 20 (out of 30)
• Terminal illness with life expectancy less than 6 months;
• Diagnosis of Parkinson's disease;
• Diagnosis of dementia with Lewy bodies;
• Unstable cardiovascular condition or any other health condition that might be deteriorated by physical exercise;
• Planned transfer from the NH to another NH/home or to surgery during the 6-month period of intervention;
• Already participating in physical exercise ≥ 2 times/week in the last 2 months prior to the date of baseline assessments.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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140 participants in 2 patient groups

Exercise

Experimental group

Description:

Exercise sessions will be done in groups of three-to-eight persons; whilst being a group-based exercise program, participants will be guided and the exercises will be adapted in an individual basis, which may increase adherence and compliance rates.

Treatment:

Other: Exercise

Social activity

Active Comparator group

Description:

Participants in this group will participate in group-based activities such as music (percussion instruments), arts and board games; no intervention on physical activity will be provided to these participants.

Treatment:

Other: Social Activity