Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients

Schön Klinik Berchtesgadener Land

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease; Alpha-1-antitrypsin-deficiency

Treatments: Procedure: exercise training

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01380626

AAT2010

Details and patient eligibility

About

Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.

Enrollment: 20 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD
• Alpha-1-Antitrypsine-deficiency, phenotype: ZZ
• FEV1%pred. <50

Exclusion criteria

• acute exacerbation
• exacerbation in the last 4 weeks

Trial design

20 participants in 1 patient group

exercise training

Experimental group

Treatment:

Procedure: exercise training