Effects of Exercise Training on Cardiovascular Health in Middle-aged Women

University of Copenhagen

Status: Completed

Conditions: Metabolic Diseases; Menopause; Cardiovascular Diseases; Blood Platelet Disorders; Cardiac Function Impaired

Treatments: Behavioral: Spinning

Study type: Interventional

Funder types: Other

Identifiers

NCT02135575

CWS-WP2CV

Details and patient eligibility

About

The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.

Enrollment: 36 patients

Sex: Female

Ages: 45 to 57 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Premenopausal (45-53 years) OR postmenopausal 50-57 years
• BMI> 18.5 and <30
• Sedentary (no regular physical activity the last 2 years)
• Plasma measurements
• Premenopausal: estradiol> 0.20 nmol/l, Follicle stimulating hormone < 22 IU/l and progesterone >2.5 nmol/l
• Postmenopausal: estradiol < 0.20 nmol/l, Follicle stimulating hormone > 22 IU/l and progesterone 0.3-2.5 nmol/l

Exclusion criteria

• Smoking
• Excessive alcohol intake
• Regular medication including hormone replacement treatment
• Chronic disease

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

Premenopausal women

Experimental group

Description:

The Premenopausal women are randomized to exercise by spinning (cycle)

Treatment:

Behavioral: Spinning

Postmenopausal women

Experimental group

Description:

The Postmenopausal women are randomized to exercise by spinning (cycle)

Treatment:

Behavioral: Spinning