Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults (BrainFit)

Universidad Santo Tomas

Status: Completed

Conditions: Cognitive Function; Obesity; Motor Activity

Treatments: Behavioral: Experimental: High Intensity Interval; Behavioral: Plus: High Intensity Interval + Resistance Training; Other: Non-exercise; Behavioral: Resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT02915913

2016-09-22

Details and patient eligibility

About

The BrainFit Study aims to examine acute effects of High Intensity Interval- vs Resistance or Combined program has benefits on Cognitive Function as well as on secretion and regulation of neurotrophic factors or neurotrophins in a cohort of sedentary, overweight adults (aged 18-30 years) from Bogota, Colombia.

Enrollment: 60 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Written informed consent.
• Interested in improving health and fitness.
• Central obesity: waist circumference ≥90cm
• Body mass index ≥ 26 kg/m(2)

Exclusion criteria

• Systemic infections.
• Weight loss or gain of >10% of body weight in the past 6 months for any reason.
• Currently taking medication that suppresses or stimulates appetite.
• Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
• Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
• Asthma.
• Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
• Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
• Any active use of illegal or illicit drugs.
• Current exerciser (>30 min organized exercise per week).
• Indication of unsuitability of current health for exercise protocol (PARQ).

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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60 participants in 4 patient groups, including a placebo group

High Intensity Interval

Experimental group

Description:

One session for 30-60 minutes of high intensity aerobic exercise

Treatment:

Behavioral: Experimental: High Intensity Interval

Resistance training

Experimental group

Description:

One session for 30-60 minutes of resistance exercise

Treatment:

Behavioral: Resistance training

Plus: High Intensity Interval + Resistance Training

Experimental group

Description:

One session for 30-60 minutes of high intensity aerobic exercise and resistance exercise

Treatment:

Behavioral: Plus: High Intensity Interval + Resistance Training

Non-exercise

Placebo Comparator group

Description:

Non-exercise

Treatment:

Other: Non-exercise