Effects of Exercise Training on Endothelial Function, Inflammation, Arterial Stiffness and Autonomic Function in CAD

Universidade do Porto

Status

Completed

Conditions

Coronary Artery Disease

Treatments

Other: Exercise-based cardiac rehabilitation program

Study type

Interventional

Funder types

Other

Identifiers

NCT01432639

PTDC/DES/113753/2009

Details and patient eligibility

About

The main purposes of this study is to analyze, in a randomized controlled trial, the effects of an exercise-based cardiac rehabilitation program (i) on biomarkers of endothelial function, (ii) on biomarkers of inflammation, (iii) on autonomic function, and (iv) on arterial stiffness in coronary artery disease patients (CAD). Additionally, the investigators aim to analyze the (v) contribution of age and the changes in traditional risk factors to the modification of the endothelial dysfunction and inflammation, and (vi) the contribution of the changes in inflammatory and endothelial function biomarkers to the modification of autonomic function and arterial stiffness.

The investigators hypothesize that exercise training will improve the autonomic function, arterial stiffness and mitigate the endothelial dysfunction and inflammation in CAD patients even in the absence of significant changes in traditional risk factors. Thus, the investigators expect with the present study to promote, develop and expand the knowledge in this field by assessing the impact of exercise on a pool of markers that provide a wide picture of the pathophysiological processes underlying CAD.

Enrollment

96 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

acute myocardial infarction

Exclusion criteria

ventricular tachyarrhythmia
uncontrolled hypertension (systolic blood pressure >180 mmHg or diastolic blood pressure >100 mmHg)
significant valvular disease
unstable angina pectoris
reduced left ventricular function (ejection fraction < 45%)
abnormal hemodynamic response
myocardial ischemia and/or severe ventricular arrhythmias during baseline exercise testing
uncontrolled metabolic disease (e.g. uncontrolled diabetes or thyroid disease)
presence of pulmonary and renal co-morbidities
peripheral artery disease and/or orthopedic limitations