Effects of Exercise Training on Left Ventricular Function in Type 2 Diabetic Patients Post Coronary Artery Bypass Graft

National Taiwan University

Status: Completed

Conditions: Post Coronary Artery Bypass Grafting; Diabetes Mellitus, Non-Insulin-Dependent; Coronary Arteriosclerosis

Treatments: Behavioral: Exercise training; Other: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT00172536

9361701147

Details and patient eligibility

About

The purpose of this study is to investigate the changes of cardiorespiratory fitness and left ventricular function in type 2 diabetes after uncomplicated coronary artery bypass graft (CABG) surgery.

We hypothesize that exercise capacity, left ventricular diastolic function, and biochemical data improves after 12-wk exercise training in patients with type 2 diabetes underwent CABG.

Full description

Patients with type 2 diabetes mellitus have higher incidence of coronary artery disease or left ventricular dysfunction, particularly diastolic dysfunction. Coronary artery bypass surgery is known to decrease the mortality rate in diabetes. Further exercise training can improve their cardiorespiratory fitness and the control of risk factors in these patients. However, the extent of improvement and the mechanism, especially the changes in left ventricular function, in diabetes after exercise training have not been fully explored.

Subjects will be assigned to the intervention or control group by randomization. Subjects in the intervention group will receive 60% VO2 max moderate aerobic exercise training, twice per week under supervision and three times per week at home, for 12 weeks. All subjects receive left ventricular function test by echocardiography and impedance cardiography, graded maximal exercise test, and biochemical analyses of sugar and lipid before and after 12 weeks. Their dietary intake and physical activity will be inquired every 4 weeks by questionnaires.

Enrollment: 65 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• well-controlled diabetes
• no history of myocardial infarction
• stable post CABG for at least 3 months

Exclusion criteria

• heart failure
• valvular disease
• abnormal kidney or liver function
• cerebrovascular disease
• primary pulmonary disease
• other systemic or acute illness that may impede the testing or training

Trial design

65 participants in 2 patient groups

Control

Other group

Description:

Received oral general education about proper diet, regular physcial activity and other medical care if necessary

Treatment:

Other: Control

Exercise training

Experimental group

Description:

Received a supervised structure treadmill training

Treatment:

Behavioral: Exercise training