Effects of Exercise Training on Respiratory Performance in Patients With Fibrosing Interstitial Lung Diseases (ET-fILD)

Alexandria University

Status: Completed

Conditions: Fibrosis Lung; Lung Diseases; Interstitial Lung Disease

Treatments: Procedure: Exercise aerobic training; Procedure: Upper, lower and breathing (ULB) exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05227443

0201313

Details and patient eligibility

About

The current study recruited patients with fibrosing interstitial lung diseases (f-ILD) whatever was the underlying pathology. The investigators aimed to compare the effects of aerobic exercises for lower limbs (LL) versus upper limbs, lower limbs, and breathing exercises (ULB) on the peak exercise measurements that was measured using cardiopulmonary exercise testing (CPET), dyspnea and health related quality of life assessment in this group of patients.

Full description

The investigators conducted a case-control study with a follow up after 6 weeks (short term). All the participants on recruited were evaluated clinically. A high resolution computed tomography (HRCT) scan of the chest was performed to confirm the diagnosis of f-ILD as well as a spirometry. All the patients were subjected to cardiopulmonary exercise testing (CPET), 6-minute walk test (6-MWT), evaluation of dyspnea using mMRC dyspnea scale, and evaluation of health related quality of life using St. George's Respiratory Questionnaire (SGRQ). The control group were followed up by telephone calls. The intervention groups (LL and ULB) were subjected randomly to aerobic exercise training for 6 weeks. After termination of all the session, the patients were re-evaluated clinically and objectively using CPET, 6-MWT, mMRC and SGRQ. Also, we evaluated the outcome of the patients (control and intervention groups) as those who died or reported exacerbation of the underlying disease were recorded.

Enrollment: 31 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients aged ≥ 18 years.
• Fibrosis interstitial lung diseases (f-ILDs) diagnosed based on HRCT radiological features.
• Restrictive or mixed pattern in forced spirometry test

Exclusion criteria

• Motor disabilities
• Cardiovascular diseases (as acute heart failure, unstable angina or recent myocardial infarction)
• Cognitive impairments
• History of cerebrovascular accident
• Active cancer
• Life expectancy less than 3 months.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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31 participants in 3 patient groups

Control

No Intervention group

Description:

The control group did not receive exercise training and the participants were informed to complete their medications provided by the treating physician.

Lower limb (LL) exercise training

Active Comparator group

Description:

All the participants in this modality of training were subjected to only lower limbs aerobic exercise training.

Treatment:

Procedure: Exercise aerobic training

Upper, lower and breathing (ULB) exercise training

Active Comparator group

Description:

All the participants in this modality of training were subjected to upper and lower limb aerobic exercise training as well as breathing training.

Treatment:

Procedure: Upper, lower and breathing (ULB) exercise