Effects of Expiratory Muscle Training on Cough Efficacy in Children and Adolescents With Cystic Fibrosis

Cigdem Emirza

Status: Completed

Conditions: Cystic Fibrosis

Treatments: Other: expiratory muscle training

Study type: Interventional

Funder types: Other

Identifiers

NCT03873688

TYL-2018-31769

Details and patient eligibility

About

Cystic fibrosis (CF) is an autosomal recessive genetic disease characterized by recurrent airway infections, affecting many systems including lung, pancreas and sweat glands. Cough is an important defense mechanism for clearing the secretions that increase in respiratory diseases. There have been studies investigating the effect of expiratory muscle training on disease groups such as chronic obstructive pulmonary disease, multiple sclerosis, parkinson's disease, and the elderly and healthy individuals. Studies that evaluating effects of expiratory muscle training in cystic fibrosis are limited in the literature. The aim of this study was to evaluate the effect of cough strength in children and adolescents with CF and the effect of expiratory muscle training program on cough strength, exercise capacity, respiratory muscle strength and quality of life.

Enrollment: 28 patients

Sex: All

Ages: 8 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosed with cystic fibrosis
• 8-18 years
• Clinically stable during last six weeks

Exclusion criteria

• hemoptysis
• low saturation (SpO2<90%)
• acute lower respiratory tract infection
• cardiac problems (heart failure, arrhythmia, cardiomyopathy, etc.)
• cognitive problems
• pneumothorax

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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28 participants in 2 patient groups

Experimental Group

Experimental group

Description:

Patients in experimental group will perform expiratory muscle training as home programme for at least five days a week, twice a day for 15 minutes at each session during six weeks by Threshold Positive Expiratory Pressure device. The intensity of training will been setted 30% of the maximal expiratory pressure level.

Treatment:

Other: expiratory muscle training

Sham Group

Sham Comparator group

Description:

In sham group, patients will perform expiratory muscle training at home for at least five days a week, twice a day for 15 minutes at each session during six weeks by Threshold Positive Expiratory Pressure device that the intensity of training will been setted 5 cm H₂O.

Treatment:

Other: expiratory muscle training