Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia (hypex)

AGIR à Dom

Status: Unknown

Conditions: Hypoxia

Treatments: Device: threshold PEEP

Study type: Observational

Funder types: Other

Identifiers

NCT01260428

10-AGIR-2

Details and patient eligibility

About

Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.

Full description

Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.

Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).

FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.

Enrollment: 20 estimated patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria :

• active (> 2 hrs/week physical activity)
• adult
• non smoking volunteers

Exclusion Criteria :

• cardiac, respiratory, neuromuscular, metabolic pathology

Trial design

20 participants in 1 patient group

healthy active subjects

Description:

with and without high altitude intolerance

Treatment:

Device: threshold PEEP