Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control

University of Manitoba

Status: Completed

Conditions: Faba Bean; Insulin; Satiety Hormones; Appetite; Post-prandial Blood Glucose

Treatments: Other: Faba bean starch smoothie; Other: Faba bean protein concentrate smoothie; Other: Non-pulse smoothie smoothie; Other: Faba bean protein isolate smoothie; Other: Faba bean powder smoothie

Study type: Interventional

Funder types: Other

Identifiers

NCT02666586

B2015:110

Details and patient eligibility

About

To describe the effect and mechanisms of action faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation in young adults (18 to 30 years).

Full description

The overall objective is to describe the effect and mechanisms of action of faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation in young adults (18 to 30 years). The specific objectives are to test the acute effects of different faba bean ingredient smoothie on: 1) post-prandial blood glucose, appetite, satiety hormone and insulin for 200 minutes, and 2) food intake 120 minutes following consumption of the faba bean smoothie. Two short-term acute studies will be conducted to meet these objectives. Both acute studies will follow a randomized, double blinded, balanced, repeated measures design and the same protocol; except one will have an ad libitum pizza meal (study 1), while the other will have a fixed pizza meal (study 2) at 120 minutes. Half the participants will have blood drawn by IV and the other half will be finger prick.

Enrollment: 60 patients

Sex: Male

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• non-smoking males
• aged 20-30 years (min/max age)
• a body mass index between 20 and 25 kg/m2 (the range generally accepted as ideal/healthy by Health and Welfare Canada)

Exclusion criteria

• individuals diagnosed with diabetes
• those on medication
• breakfast skippers
• on an energy restricted diet
• this study excludes females because appetite and blood glucose during the female menstruation cycle changes due to fluctuations in hormones

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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60 participants in 5 patient groups, including a placebo group

Control smoothie

Placebo Comparator group

Description:

Control smoothie with 32 g corn maltodextrin without added faba bean fractions.

Treatment:

Other: Faba bean protein isolate smoothie

Other: Faba bean powder smoothie

Other: Faba bean protein concentrate smoothie

Other: Faba bean starch smoothie

Faba Bean powder smoothie

Experimental group

Description:

Breakfast smoothie with 32 g whole faba bean powder.

Treatment:

Other: Faba bean protein isolate smoothie

Other: Non-pulse smoothie smoothie

Other: Faba bean protein concentrate smoothie

Other: Faba bean starch smoothie

Faba bean protein concentrate smoothie

Experimental group

Description:

Breakfast smoothie with 32 g faba bean protein concentrate.

Treatment:

Other: Faba bean protein isolate smoothie

Other: Faba bean powder smoothie

Other: Non-pulse smoothie smoothie

Other: Faba bean starch smoothie

Faba bean starch smoothie

Experimental group

Description:

Breakfast smoothie with 33 g faba bean starch.

Treatment:

Other: Faba bean protein isolate smoothie

Other: Faba bean powder smoothie

Other: Non-pulse smoothie smoothie

Other: Faba bean protein concentrate smoothie

Faba bean protein isolate smoothie

Experimental group

Description:

Breakfast smoothie with 32 g faba bean protein isolate.

Treatment:

Other: Faba bean powder smoothie

Other: Non-pulse smoothie smoothie

Other: Faba bean protein concentrate smoothie

Other: Faba bean starch smoothie