Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat (FEIGH)

University of Aarhus

Status: Completed

Conditions: Healthy

Treatments: Other: Fasting; Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT00817440

16.12.2008

Details and patient eligibility

About

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.

Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.

In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Enrollment: 8 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy men
• Body mass index (BMI) 20-26
• age 18-45 years

Exclusion criteria

• any kind of disease
• any use of medicine

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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8 participants in 3 patient groups

Control

No Intervention group

Description:

control: muscle and fat biopsies and basal aminoacid and glucose turnover

Exercise

Experimental group

Description:

1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.

Treatment:

Other: Exercise

Fasting

Experimental group

Description:

3 days of fasting and then the same as arm 1

Treatment:

Other: Fasting