Effects of Fasting Mimetic Diet on Nephropatic Patients

University of Roma La Sapienza

Status: Completed

Conditions: Renal Insufficiency, Chronic

Treatments: Dietary Supplement: Fasting mimetic diet

Study type: Interventional

Funder types: Other

Identifiers

NCT04490252

FMD1

Details and patient eligibility

About

Fasting mimetic diet (FMD) showed positive effects on cardiovascular risks. Purpose of the trial is to evaluate FMD effects on patients affected by chronic kidney disease (CKD), through the stimulation of kidney stem cells and improving cardiovascular and metabolic status.

From April 2018, the investigators enrolled 13 patients (7 male) with an history of primary glomerulonephritis (GMN) and an eGFR between 60 ml/min and 30 ml/min. Exclusion criteria are: age <18 y.o., age> 65 y.o., secondary GMN, severe heart failure (NYHA IV),ongoing infectious diseases, ongoing neoplasia, hepatic diseases, COPD, inflammatory bowel disease, history of stroke, history of acute coronary disease less than 3 months, pregnancy, refuse informed consent.

Enrollment: 13 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of primary glomerulonephritis
• eGFR between 60 ml/min and 30 ml/min
• age between 18-65 years old

Exclusion criteria

• secondary GMN
• severe heart failure (NYHA IV)
• ongoing infectious diseases
• ongoing neoplasia,
• hepatic diseases
• COPD,
• inflammatory bowel disease
• history of stroke
• history of acute coronary disease less than 3 months
• pregnancy
• refuse informed consent.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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13 participants in 2 patient groups

Free diet

No Intervention group

Description:

Free diet

FMD

Experimental group

Description:

Fasting mimetic diet for 5 days, next cycle after 25 days of free diet

Treatment:

Dietary Supplement: Fasting mimetic diet