Effects of Fatty and Lean Fish Intake on Cardiovascular Risk Factors in Subjects With Coronary Heart Disease

University of Eastern Finland

Status: Completed

Conditions: Inflammation; Arrhythmia; Blood Pressure

Treatments: Other: Dietary intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT00720655

FISH6417

Details and patient eligibility

About

The aim of the study is to examine the effects of fatty fish and white (lean) fish on cardiovascular disease risk factor levels in subjects with established coronary heart disease using multiple medications. The main end points are blood pressure, serum lipids, inflammatory markers, arrhythmias and gene expression in peripheral mononuclear cells. The study design was a controlled, parallel study lasting 8 weeks with three diet groups: fatty fish, white fish and control group (lean pork, beef or chicken).

Enrollment: 33 patients

Sex: All

Ages: Under 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• myocardial infarction or unstable ischemic attack
• use of beta blockers
• normal sinus rhythm
• fasting serum triglyceride less or equal to 3.5 mmol/l
• fasting serum cholesterol less or equal to 8 mmol/l
• BMI 18.5-30 kg/m2
• fasting plasma glucose less or equal to 7 mmol/l

Exclusion criteria

• diabetes
• use of other antiarrhythmic medications than beta blockers
• atrial fibrillation
• use of psychotropic medications
• abnormal liver, thyroid or kidney function
• inflammatory bowel disease
• excessive use of alcohol
• use of fish oil supplements or high habitual intake of fish

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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33 participants in 3 patient groups, including a placebo group

Fatty fish

Experimental group

Treatment:

Other: Dietary intervention

Other: Dietary intervention

Other: Dietary intervention

Lean Fish

Experimental group

Treatment:

Other: Dietary intervention

Other: Dietary intervention

Other: Dietary intervention

Control diet

Placebo Comparator group

Treatment:

Other: Dietary intervention

Other: Dietary intervention

Other: Dietary intervention