Effects of Fish Oil on Platelet Function and Coagulation (FOILP)

R

Region Skane

Status

Completed

Conditions

Platelet Aggregation, Spontaneous
Surgery
Atherosclerosis

Treatments

Drug: Fish oil

Study type

Interventional

Funder types

Other

Identifiers

NCT03048981
Fish oil and platelet function

Details and patient eligibility

About

Many patients undergoing surgery use naturopathic drugs, including fish oil. Fish oil has been reported to increase bleeding in patients through inhibiting platelet aggregation and prolonging of clot formation time. The Swedish Medical Products Agency recommends that patients stop taking the naturopathic medicines including fish oil two weeks prior planed surgery. The aim of this study is to examine the effects of fish oil given to healthy volunteers using point of care coagulation assessment and flow dependent Cellix instrument before and after intake of fish oil.

Full description

Healthy volunteers will be given maximum dose of fish oil for 7 days. Blood samples will be collected before and immediately after the 7 days of intake and analysed using point of care coagulation assessment instruments and flow dependent platelet aggregation using a microfluid flow controlled system (Cellix). For point of care coagulation assessment the multiple electrode platelet aggregometer Multiplate, the viscoelastic rotational thromboelastometers ROTEM and Sonoclot will be used. Flow cytometry may also be utilized.

Enrollment

12 patients

Sex

All

Ages

19 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Non smoking healthy volunteers with written consent to participate

Exclusion criteria

Medication affecting coagulation or platelets within 14 days priori to inclusion

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

12 participants in 1 patient group

Fish oil intake
Experimental group
Description:
Healthy volunteers given maximum dose of fish oil for 10 days.
Treatment:
Drug: Fish oil

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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