Effects of Fish Oil on Platelet Function and Coagulation (FOILP)

Region Skane

Status: Completed

Conditions: Platelet Aggregation, Spontaneous; Surgery; Atherosclerosis

Treatments: Drug: Fish oil

Study type: Interventional

Funder types: Other

Identifiers

NCT03048981

Fish oil and platelet function

Details and patient eligibility

About

Many patients undergoing surgery use naturopathic drugs, including fish oil. Fish oil has been reported to increase bleeding in patients through inhibiting platelet aggregation and prolonging of clot formation time. The Swedish Medical Products Agency recommends that patients stop taking the naturopathic medicines including fish oil two weeks prior planed surgery. The aim of this study is to examine the effects of fish oil given to healthy volunteers using point of care coagulation assessment and flow dependent Cellix instrument before and after intake of fish oil.

Full description

Healthy volunteers will be given maximum dose of fish oil for 7 days. Blood samples will be collected before and immediately after the 7 days of intake and analysed using point of care coagulation assessment instruments and flow dependent platelet aggregation using a microfluid flow controlled system (Cellix). For point of care coagulation assessment the multiple electrode platelet aggregometer Multiplate, the viscoelastic rotational thromboelastometers ROTEM and Sonoclot will be used. Flow cytometry may also be utilized.

Enrollment: 12 patients

Sex: All

Ages: 19 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non smoking healthy volunteers with written consent to participate

Exclusion criteria

• Medication affecting coagulation or platelets within 14 days priori to inclusion

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Fish oil intake

Experimental group

Description:

Healthy volunteers given maximum dose of fish oil for 10 days.

Treatment:

Drug: Fish oil