"Effects of Fluid Status and Regional Cerebral Oxygenation on Postoperative Cognitive Dysfunction in Patients Undergoing Lower Extremity Surgery Under General and Spinal Anesthesia." (AECGSKD002)

Goztepe Training and Research Hospital

Status: Active, not recruiting

Conditions: Postoperative Cognitive Deficit (POCD)

Study type: Observational

Funder types: Other

Identifiers

NCT07302061

AECGSKD002

Details and patient eligibility

About

We frequently encounter cognitive impairments in patients over 65 undergoing Lower extremity surgery, depending on comorbidities and the choice of anesthesia method. The current development of neuraxial anesthesia techniques and close monitoring devices helps us prevent and detect cognitive impairment early in these patients. In this study, we aimed to investigate the effects of different anesthesia techniques (general anesthesia/spinal anesthesia) applied in orthopedic cases on patient fluid status (pleth variablity index) and regional cerebral oxygenation (NIRS), and their relationship with cognitive dysfunction.

Enrollment: 60 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over the age of 65
• Patients with an American Society of Anesthesiologists (ASA) score of II-III
• Patients with a Mini Mental State Examination (MMSE) score of ≥24 on the first day before surgery

Exclusion criteria

• Patients with coagulation disorders
• Patients with a history of anticoagulant medication use
• Patients with advanced organ failure
• Patients with Alzheimer's disease or advanced dementia
• Patients with allergies to the medications used in the study
• Mental Retardation
• Patients with a wound infection at the site of spinal anesthesia
• Patients with a history of cerebrovascular hemorrhage
• Patients who did not consent;

Trial design

60 participants in 2 patient groups

General Anesthesia

Spinal anesthesia