Effects of Fructose and Exercise on Hepatic Lipid Metabolism (FRUCTEXER)

University of Lausanne (UNIL)

Status: Completed

Conditions: Metabolism

Treatments: Behavioral: weight maintenance, low sugar diet; Behavioral: weight maintenance, high fructose diet; Behavioral: weight maintenance, high fructose diet+ exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01121003

Protocole 220/09

Details and patient eligibility

About

8 healthy male volunteers will be studied each on 3 occasions, ie

• after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity
• after 4 days on a weight maintenance diet containing 30% fructose + low physical activity
• after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Enrollment: 8 estimated patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age between 18 and 30 years
• males
• BMI between 19 and 25
• low to moderate physical activity (< 3 sessions/week)

Exclusion criteria

• smoking
• consumption of alcohol>50g/week
• consumption of drugs or illicit substances
• food allergies

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 3 patient groups

Low fructose diet/no exercise

Other group

Treatment:

Behavioral: weight maintenance, low sugar diet

high fructose diet/no exercise

Experimental group

Treatment:

Behavioral: weight maintenance, high fructose diet

high fructose diet+exercise

Experimental group

Treatment:

Behavioral: weight maintenance, high fructose diet+ exercise