Effects of Fruit Juices on Hormone Metabolism

Benedictine University

Status: Unknown

Conditions: Cortisol

Treatments: Other: Grapefruit juice; Other: Apple juice

Study type: Interventional

Funder types: Other

Identifiers

NCT02187328

Ben-0614a

Details and patient eligibility

About

The purpose of this study is to determine whether grapefruit juice alters the metabolism of cortisol following intense exercise.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Young men and women, not taking medications known to alter glucocorticoid metabolism

Exclusion criteria

• Diabetes, uncontrolled hypertension, obesity, any medication known to interact with grapefruit juice

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 2 patient groups, including a placebo group

Grapefruit juice

Experimental group

Description:

12.5 OZ Grapefruit juice: Subject will ingest grapefruit juice 12.5 OZ twice on the day of their scheduled laboratory visit. Once in the morning and once in the afternoon prior to their evening visit

Treatment:

Other: Grapefruit juice

Apple juice

Placebo Comparator group

Description:

10.5 OZ Apple juice: Subject will ingest apple juice 10.5 OZ twice on the day of their scheduled laboratory visit. Once in the morning and once in the afternoon 3 hours prior to their evening visit.

Treatment:

Other: Apple juice