Effects of Gastric Bypass Surgery on Bile Acid Homeostasis

Hvidovre University Hospital

Status

Completed

Conditions

Obesity

Study type

Observational

Funder types

Other

Identifiers

NCT03475849

GAL-CAJ-16

Details and patient eligibility

About

The purpose of this study is to determine whether the bile acid circulation is changed after gastric bypass surgery. Further, to account for how the changed anatomy of the gut influences how the bile acid and food is mixed in the gut and how this is associated with the changes in gut hormone release after the surgery.

Our hypothesis is that bile acid reabsorption from the gut is increased as animal models suggest so and bile acid blood concentration increases after surgery.

Enrollment

40 patients

Sex

All

Ages

25 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age between 25 and 65 years
For patients: uncomplicated Roux-en-Y Gastric Bypass surgery more than 12 months before study initiation
For controls: Age, BMI and gender matched with patient group

Exclusion criteria

Previous removal of gall bladder or other abdominal surgeries except appendectomy (and gastric bypass surgery for patient group)
Known liver disease or thyroid disease requiring antithyroid medication
Chronic gastrointestinal symptoms
Any chronic disease interfering with, or susceptive of interfering with appetite or gastrointestinal function
Any medication interfering with, or susceptive of interfering with appetite or gastrointestinal function
Smoking within the last month
Alcohol consumption above 168 grams per week
Currently pregnant or breast-feeding
Anaemia with haemoglobin <6,5 mmol/L (<117 mg/dl)
Loss or gain of more than 3 kg within the last 3 months