Effects of Ginger Supplementation on NF-KB in Peripheral Blood Mononuclear Cells in Type 2 Diabetes Mellitus

T

Tehran University of Medical Sciences

Status

Completed

Conditions

Type 2 Diabetes Mellitus

Treatments

Dietary Supplement: placebo
Dietary Supplement: Ginger

Study type

Interventional

Funder types

Other

Identifiers

NCT02666807
TehranUMS

Details and patient eligibility

About

This study evaluates the effect of ginger on NF-KB level in Peripheral Blood Mononuclear Cells in type 2 diabetic patients. Half of patients will receive ginger, while the other half will receive placebo.

Full description

ginger is a plant with lots of phytochemicals which have antioxidant effects. It reduces the NF-KB levels in the cells because of its antioxidant effects. It can reduces insulin resistance as a result of NF-KB reduction in diabetes.

Enrollment

50 patients

Sex

All

Ages

30 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • type 2 of diabetes diagnosed for 1 to 10 years
  • age 30-60 years
  • BMI = 18.5-35 kg/m*m
  • treatment with Metformin or Glibenclamide

Exclusion criteria

  • Treatment with insulin
  • Weight loss more than 10% in 6 months
  • Treatment with TZDs (thiazolidinediones)
  • Pregnancy and breast feeding
  • Smoking and alcohol consumption
  • Multivitamin-mineral and polyphenols and omega-3 and 6 supplementation in the last 3 months and during study
  • Ginger supplementation and herbal medicines
  • Anticoagulation consumption such as heparin and warfarin
  • NSAIDs such as diclofenac and salicylate drugs such as aspirin, corticosteroids such as prednisone consumption during 1 month ago and during the study
  • Infectious and inflammatory diseases such as rheumatoid arthritis
  • Impaired hepatic, renal and gastrointestinal function
  • Cancer
  • Currently suffering from acute illness that needs medical treatment

Trial design

50 participants in 2 patient groups, including a placebo group

Ginger
Experimental group
Description:
Ginger (Zingiber officinale Roscoe) 500 mg capsules (2000 mg per day) by mouth twice daily (BID) for 10 weeks
Treatment:
Dietary Supplement: Ginger
Placebo
Placebo Comparator group
Description:
Placebo matching with ginger 0 mg capsules by mouth twice daily (BID) for 10 weeks Placebo twice daily
Treatment:
Dietary Supplement: placebo

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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