Effects of Ginger Supplementation on NF-KB in Peripheral Blood Mononuclear Cells in Type 2 Diabetes Mellitus

Tehran University of Medical Sciences

Status

Completed

Conditions

Type 2 Diabetes Mellitus

Treatments

Dietary Supplement: placebo

Dietary Supplement: Ginger

Study type

Interventional

Funder types

Other

Identifiers

NCT02666807

TehranUMS

Details and patient eligibility

About

This study evaluates the effect of ginger on NF-KB level in Peripheral Blood Mononuclear Cells in type 2 diabetic patients. Half of patients will receive ginger, while the other half will receive placebo.

Full description

ginger is a plant with lots of phytochemicals which have antioxidant effects. It reduces the NF-KB levels in the cells because of its antioxidant effects. It can reduces insulin resistance as a result of NF-KB reduction in diabetes.

Enrollment

50 patients

Sex

All

Ages

30 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

type 2 of diabetes diagnosed for 1 to 10 years
age 30-60 years
BMI = 18.5-35 kg/m*m
treatment with Metformin or Glibenclamide

Exclusion criteria

Treatment with insulin
Weight loss more than 10% in 6 months
Treatment with TZDs (thiazolidinediones)
Pregnancy and breast feeding
Smoking and alcohol consumption
Multivitamin-mineral and polyphenols and omega-3 and 6 supplementation in the last 3 months and during study
Ginger supplementation and herbal medicines
Anticoagulation consumption such as heparin and warfarin
NSAIDs such as diclofenac and salicylate drugs such as aspirin, corticosteroids such as prednisone consumption during 1 month ago and during the study
Infectious and inflammatory diseases such as rheumatoid arthritis
Impaired hepatic, renal and gastrointestinal function
Cancer
Currently suffering from acute illness that needs medical treatment