Effects of GLP-1 Agonists on Gastric Volume

Medical University of South Carolina (MUSC)

Status: Completed

Conditions: Gastric Content Aspiration; Diabetes; GLP-1; Glucagon-like Peptide 1

Treatments: Diagnostic Test: Gastric Ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT05854979

Pro00128783

Details and patient eligibility

About

This study will enroll patients ages 18 and over who have a diagnosis of diabetes, are undergoing an elective surgery under general anesthesia and 1) are taking a GLP-1 receptor agonist medication, or 2) not taking a GLP-1 receptor agonist medication. The patients will have a gastric ultrasound prior to surgery to measure any retained gastric contents. The primary goal is to assess the effect of subcutaneous injectable GLP-1 agonists on preoperative gastric volume in fasted, diabetic surgical patients.

Enrollment: 210 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Age greater than or equal to 18 years old
• Diagnosed with diabetes (listed on medical record, Hgb A1C greater than or equal to 6.5%, fasting blood glucose greater than or equal to 126mg/dL, and/or on medical treatment for diabetes)
• One of the following groups:
• Taking a GLP-1 Medication
• Not taking a GLP-1 Medication
• ASA Physical Classification Status 1-3
• Scheduled for elective surgery under general anesthesia
• Appropriately fasted per ASA Fasting Guidelines 201712

Exclusion Criteria

• BMI greater than 40
• Previous gastric/esophageal surgery
• Abnormal gastric anatomy
• Pregnancy
• Inability or unwillingness of subject to give informed consent
• Non-English Speaking

Trial design

210 participants in 2 patient groups

Diabetics taking a GLP-1 receptor agonist

Treatment:

Diagnostic Test: Gastric Ultrasound

Diabetics not taking a GLP-1 receptor agonist (control)

Treatment:

Diagnostic Test: Gastric Ultrasound