Effects of Gonadotropin Replacement Therapy on Metabolic Parameters in Patients With Hypogonadism

Gulhane School of Medicine

Status

Completed

Conditions

Idiopathic Hypogonadotropic Hypogonadism

Treatments

Drug: human chorionic gonadotropin, human menopausal gonadotropin

Study type

Observational

Funder types

Other

Identifiers

NCT02728440

FB03232016

Details and patient eligibility

About

Effects of gonadotrophin replacement therapy Lipid Profile and Oxidative Stress Parameters of Patients with Idiopathic Hypogonadotropic Hypogonadism

Full description

30 male patients diagnosed with IHH and a control group of 20 healthy cases with similar age and BMI were included in the study. The levels of advanced oxidation protein products (AOPP), thiol, malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8-OHdG) and the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-K), low density lipoprotein (LDL-K), Apolipoprotein A1 (ApoA1) and Apolipoprotein B100 (ApoB100) were measured before and after gonadotrophin therapy.

Enrollment

30 patients

Sex

Male

Ages

22 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Serum testosterone concentration < 300ng/dL Absence of a pituitary or hypothalamic mass lesions, Presence of gonadotropin response to GnRH, -

Exclusion criteria

diabetes mellitus, arterial hypertension other hormone deficiencies