Effects of Grape Juice With Breakfast on Glycemia and Cognitive Function in Healthy Adults

Purdue University

Status: Completed

Conditions: Appetitive Behavior; Glycemic Response

Treatments: Other: Concord Grape Juice; Other: Low flavonoid beverage; Other: Low flavonoid low essence beverage

Study type: Interventional

Funder types: Other

Identifiers

NCT03409497

055-049

Details and patient eligibility

About

Assess the impact of 100% grape juice with a meal on postprandial glycemic response and subsequent appetite, food intake and cognitive function.

Full description

Investigators earlier studies and published literature suggest that the phenolic content and strong flavor intensity of 100% Concord grape juice hold potential beneficial effects on blood sugar levels. Investigators aim to better understand the consumption of 100% grape juice with a meal modifies appetite and glycemia acutely and over the day using a 24 hour glucose monitor.

Enrollment: 40 patients

Sex: All

Ages: 25 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 25.0-34.9 kg/m2
• Willingness to eat all test foods
• Low consumer of tea and coffee, willingness to refrain from both during the 48 hours prior to test days and on the test day
• Fasting blood glucose below 6.1mmol/l via capillary finger-stick blood sample using a SureStep glucometer (Lifescan, Milpitas, CA)

Exclusion criteria

• Taking medications known to affect glycemia, lipid metabolism or appetite
• Body weight fluctuation of >5kg in the past 3 months
• Taking vitamin or other supplements
• Smokers
• Acute or Chronic disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 3 patient groups

Concord Grape Juice

Active Comparator group

Description:

Concord Grape Juice

Treatment:

Other: Concord Grape Juice

Low flavonoid low essence beverage

Sham Comparator group

Description:

Low flavonoid low essence beverage

Treatment:

Other: Low flavonoid low essence beverage

Low flavonoid beverage

Sham Comparator group

Description:

Low flavonoid beverage

Treatment:

Other: Low flavonoid beverage