Effects of Gut Peptides on Bone Remodeling (KS-3)

University of Copenhagen

Status: Completed

Conditions: Healthy

Treatments: Other: GLP-2+GIP; Other: Placebo; Other: Glucose-dependent insulinotropic polypeptide (GIP); Other: Glucagon-Like Peptide-2 (GLP-2)

Study type: Interventional

Funder types: Other

Identifiers

NCT03574064

UCPH-KS-3-18

Details and patient eligibility

About

We will investigate effects of gut hormones on bone remodeling.

Enrollment: 10 patients

Sex: Female

Ages: 50 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Women Age above 50 years Postmenopausal Caucasian BMI 18.5 to 28.0 kg/m2.

Exclusion criteria

Smoking Medication believed to influence study outcome Weight change more than 3 kg whitin the last 3 months Overweight surgery Intestinal surgery Hgb<7,0 mmol/L Decreased renal function

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 4 patient groups, including a placebo group

GLP-2

Experimental group

Description:

Glucagon-Like Peptide-2 (GLP-2)

Treatment:

Other: Glucagon-Like Peptide-2 (GLP-2)

GIP

Experimental group

Description:

Glucose-dependent Insulinotropic polypeptide (GIP)

Treatment:

Other: Glucose-dependent insulinotropic polypeptide (GIP)

GLP-2+GIP

Experimental group

Description:

GLP-2+GIP

Treatment:

Other: GLP-2+GIP

Placebo

Placebo Comparator group

Description:

Placebo

Treatment:

Other: Placebo