Effects of H1-Antagonist on Cognition

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Cognition

Treatments: Drug: dexchlorpheniramine, lorazepam

Study type: Interventional

Funder types: Other

Identifiers

NCT00846950

06-3-075

Details and patient eligibility

About

The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.

Full description

The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.

Enrollment: 18 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy as determined by a physician

Exclusion criteria

• present or history of any neurological of psychiatric disease
• present or history of any substance abuse

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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18 participants in 1 patient group

healthy volunteers

Experimental group

Treatment:

Drug: dexchlorpheniramine, lorazepam