Effects of HD-tDCS During Slow-wave Sleep on Associative Memory

WANG KAI

Status: Completed

Conditions: Healthy Adults; Transcranial Direct Current Stimulation

Treatments: Device: sham high-definition transcranial direct current stimulation (HD-tDCS); Device: high-definition transcranial direct current stimulation (HD-tDCS)

Study type: Interventional

Funder types: Other

Identifiers

NCT07063264

HD-tDCS-healthy adults

Details and patient eligibility

About

To evaluate the effects of afternoon naps and high-definition transcranial direct current stimulation (HD-tDCS) over the left dorsolateral prefrontal cortex (DLPFC) in associative memory (AM)

Full description

Healthy adults will be randomized into three groups: a sleep with active stimulation (Sleep-A) group will receive active anode HD-tDCS during slow-wave sleep (SWS) of non-rapid eye movement sleep (NREM) at afternoon nap, a sleep with sham stimulation (Sleep-S) group will receive afternoon nap with sham stimulation, and wake with active stimulation (Wake-A) group will receive active anode HD-tDCS during wakefulness. An anode stimulation electrode will be placed in F3 (10/20 system) which intend to target the left DLPFC, and four cathodes will be placed at FCz, AFz, F7, and C5 (10/20 system). The face-word AM task and other multidimensional neuropsychological tasks will be performed before and after afternoon napping.

Enrollment: 87 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 18-30 years
• healthy adults

Exclusion criteria

• with pacemakers, skull cavities or cracks；
• intolerance of high-definition transcranial direct current stimulation (HD-tDCS) adverse reactions；
• left-handed；
• diagnosed with severe mental disorders, or involved in other experiments.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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87 participants in 3 patient groups, including a placebo group

sleep with active stimulation (Sleep-A)

Active Comparator group

Description:

Participants will receive active anode HD-tDCS during slow-wave sleep (SWS) of non-rapid eye movement sleep (NREM) at afternoon nap. An anode stimulation electrode will be placed in F3 (10/20 system) which intended to target the left DLPFC, and four cathodes will be placed at FCz, AFz, F7, and C5 (10/20 system)

Treatment:

Device: high-definition transcranial direct current stimulation (HD-tDCS)

sleep with sham stimulation (Sleep-S)

Placebo Comparator group

Description:

Participants will receive afternoon nap with sham stimulation. A 30-s rising current until 2 mA is reached, with a 30-s decline immediately at the beginning and end of the stimulation section

Treatment:

Device: sham high-definition transcranial direct current stimulation (HD-tDCS)

wake with active stimulation (Wake-A)

Sham Comparator group

Description:

Participants will receive active anode HD-tDCS during wakefulness. They will receive HD-tDCS stimulation for 25 minutes while awake, then spent free time in the sleep monitoring room, remaining awake throughout the napping period

Treatment:

Device: high-definition transcranial direct current stimulation (HD-tDCS)