Effects of HICT and Intermittent Fasting on PCOS

Riphah International University

Status: Enrolling

Conditions: PCO; Polycystic Ovary Syndrome

Treatments: Other: High Intensity Circuit training (HICT); Other: Combination of HICT and IF; Other: Intermittent Fasting (IF)

Study type: Interventional

Funder types: Other

Identifiers

NCT06302166

REC/MS-PT/01720

Details and patient eligibility

About

The goal of this randomized controlled trial is to compare the effects of High intensity circuit training, Intermittent Fasting, and their combination on PCOS morphology, Anthropometrics, clinical hyperandrogenism and body image concerns in females with PCOS.

Participants will be divided into three groups who will receive High intensity circuit training, Intermittent fasting and their combination. The outcomes will be PCOS morphology, anthropometrics', clinical hyperandrogenism and body image concerns.

Enrollment: 33 estimated patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Unmarried females

• Diagnosed with PCOS Phenotype A based on Rotterdam Criteria:

  • PCOM on US
  • Ovulatory dysfunction
  • Clinical Hyperandrogenism (Hirsutism modified Ferriman Gallway score ≥ 8)

• Not engaged in any regular lifestyle intervention for <3 Months prior to inclusion

Exclusion criteria

• Use of Estrogen, Progestin or combination.
• Taking medications or supplements for Insulin resistance < 3 months prior to the inclusion
• Type I or II DM
• Hypo/hyperthyroidism
• BMI ≥27 (Obese according to BMI Asia)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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33 participants in 3 patient groups

High Intensity circuit training (HICT)

Active Comparator group

Description:

For the group allocated with exercise, high intensity circuit training (HICT) of three supervised sessions per week for 20-30 mins will be given. HICT commenced after 10 mins low to moderate intensity warm up and after completing session ended with 10 mins cool down. Intensity of exercise will be measured on borg rating of perceived exertion (RPE). Perceived exertion is how hard you feel like your body is working. Although this is a subjective measure your exertion rating based on a 0 to 10 modified borg rating scale may provide a fairly good estimate of your actual heart rate during physical activity. 0 perceiving "no exertion at all" to 10 perceiving a "maximal exertion" of effort. A moderate intensity activity will be at 3-5 perceiving "somewhat hard", similarly 6-10 will be perceived as high intensity activity.

Treatment:

Other: High Intensity Circuit training (HICT)

Intermittent fasting (IF)

Active Comparator group

Description:

For the group allocated with intermittent fasting, a time restricted feeding (TRF) methodology will be administered. The Fasting protocol will begin with a 12-hour eating window (12:12) and will gradually go down to 8 hours eating window over a period of 8 weeks (16:8).

Treatment:

Other: Intermittent Fasting (IF)

Combination of HICT and IF

Active Comparator group

Description:

The group allocated with both exercise and intermittent fasting will be provided with both HICT for three sessions per week and 8 hours' time restricted eating.

Treatment:

Other: Combination of HICT and IF