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Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch

H

Hjalte Holm Andersen

Status and phase

Completed
Phase 2
Phase 1

Conditions

Pruritus

Treatments

Drug: Capsaicin 24 Hours
Other: Qutenza Demo Patch
Drug: Capsaicin 1 Hour

Study type

Interventional

Funder types

Other

Identifiers

NCT02769910
N-20160026

Details and patient eligibility

About

The purpose of this project is to investigate the effect of capsaicin-induced neurogenic inflammation with three different intensities on itch subsequently induced by histamine and cowhage. The hypothesis is that capsaicin-induced pre-established neurogenic inflammation significantly increases susceptibility to itch provocations with cowhage and histamine.

Enrollment

16 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy men and women
  • 18-60 years
  • Caucasian descent
  • Speak and understand English

Exclusion criteria

  • Pregnancy or lactation
  • Drug addiction defined as any use of cannabis, opioids or other drugs
  • Previous or current neurologic, musculoskeletal or mental illnesses
  • Lack of ability to cooperate
  • Current use of medications that may affect the trial
  • Skin diseases
  • Consumption of alcohol or painkillers 24 hours before the study days and between these
  • Moles or tattoos in the area to be irradiated
  • Exposure of the irradiated area to UV radiation (e.g., sun) 48 hours before the study days and between these
  • Acute or chronic pain
  • Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

16 participants in 2 patient groups

Cowhage
Other group
Description:
Cowhage is used to induce non-histaminergic itch on the volar forearm at the locations treated with Capsaicin 24 Hours, Capsaicin 1 Hours and Qutenza Demo Patch.
Treatment:
Drug: Capsaicin 1 Hour
Other: Qutenza Demo Patch
Drug: Capsaicin 24 Hours
Histamine
Other group
Description:
Histamine is used to induce histaminergic itch on the volar forearm at the locations treated with Capsaicin 24 Hours, Capsaicin 1 Hour and Qutenza Demo Patch.
Treatment:
Drug: Capsaicin 1 Hour
Other: Qutenza Demo Patch
Drug: Capsaicin 24 Hours

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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