Effects of High Frequency rTMS Combined Motor Learning on Upper Limb Motor Function in Subacute Stroke

Chungnam National University Sejong Hospital

Status: Completed

Conditions: Stroke, Acute; Hemiplegia

Treatments: Device: Sham-rTMS; Behavioral: ML; Device: HF-rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT05176613

2016071HR

Details and patient eligibility

About

This study is to present the effect of a program combining high frequency repetitive transcranial magnetic stimulation with motor learning on upper limb motor function and grip strength and activities of daily motion in patients with subacute stroke.

Purpose : This study was to investigate the effects of high frequency repetitive transcranial magnetic stimulation combined with motor learning effects motor function and grip force for upper limbs and activities of daily living of subacute stroke patients.

Subjects : Thirty individuals with subacute stroke, satisfying the selection criteria, were selected for this study. Subject were randomly allocated into 14 high frequency repetitive transcarnial magnetic stimulation+motor learning group(experimental group), 16 sham repetitive transcranial magnetic stimulation+motor learning group(control group).

Intervention : 12 sessions, 3d/wk, 4week Studies : upper limb functional assessment(FMA-U/L, BBT), hand grip force assessment(disital hand dynamometer), activities daily of living assessment(K-MBI) Evaluation : 1)pre test 2)post test

Enrollment: 30 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hemiplegia from stroke
• Factors within six months of onset
• Found to have subcortex damage through diagnoses of magnetic resonance imaging(MRI)
• Had motor defects on the damaged upper extremities
• Korean version Mini mental state examination(MMSE-K) score greater than 24 points

Exclusion criteria

• Permanent damage such as heart vein
• Upper limb fractures
• Neurological damage such as Parkinson's, multiple sclerosis
• Other reasons limiting upper limb movement
• Epilepsy or family history of epilepsy
• wearing a metal tube in skull or pacemaker
• The lesion at occipital lobe

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

HF-rTMS and ML

Experimental group

Description:

High frequency Repetitive Transcranial Magnetic Stimulation and Motor Learning(Experimental group)

Treatment:

Device: HF-rTMS

Behavioral: ML

Sham-rTMS and ML

Sham Comparator group

Description:

Sham Repetitive Transcranial Magnetic Stimulation and Motor Learning

Treatment:

Behavioral: ML

Device: Sham-rTMS