Effects of High-intensity Interval Training on Myocardial Strain in Metabolic Syndrome Patients

University of Castilla-La Mancha

Status: Completed

Conditions: Myocardial Dysfunction; High-Intensity Interval Training; Metabolic Syndrome

Treatments: Behavioral: High-intensity interval training

Study type: Interventional

Funder types: Other

Identifiers

NCT06262256

HIIT-GLS-METS

Details and patient eligibility

About

the effects of high-intensity interval training on myocardial function will be studied in a group of patients under medical treatment for the components of metabolic syndrome.

Full description

Objective: To analyze the effects of high-intensity interval training (HIIT) on myocardial function of metabolic syndrome patients.

Methods and design. Randomized clinical trial with a control group. Project was developed in association with the regional general hospital. Pre and post-intervention evaluation after 16 weeks of training for the HIIT group.

Subjects: Recruited using adverts published on public medical center boards. Up to 30 subjects per group (HIIT and CONTROL) will be recruited (at least 20% women) Measurements. Echocardiography: Global longitudinal strain (GLS), Mitral filling parameters, myocardial dimensions, and myocardial wall thickness.

Cardiorespiratory fitness: Maximal oxygen consumption, Maximal power output, Maximal oxygen pulse.

Clinical: Metabolic syndrome components and derived variables (e.g., triglycerides/high-density lipoprotein ratio) Body composition by anthropometric measurements and dual-energy X-ray absorptiometry.

Enrollment: 80 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of metabolic syndrome.
• Capacity to exercise on a stationary bike
• Inhabitant of the province of Toledo

Exclusion criteria

• Untreated cardiovascular disease with hemodynamic instability
• Untreated respiratory disease, symptomatic.
• Untreated metabolic disease.
• Untreated renal disease requiring dialysis.
• Contraindications for high-intensity exercise training

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Control

No Intervention group

Description:

Regular medical treatment for patients with metabolic syndrome.

High-intensity interval training

Experimental group

Description:

Regular medical treatment for patients with metabolic syndrome plus, 16 weeks of high-intensity interval training (3-times/week, 50 min/session conducted on stationary bike).

Treatment:

Behavioral: High-intensity interval training