Effects of High-intensity Training Compared to Resistance Training in Cancer Patients Undergoing Radiotherapy

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Completed

Conditions: Rectum Cancer; Head and Neck Cancer; Prostate Cancer

Treatments: Behavioral: High-intensity interval training; Behavioral: Resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT03252821

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Details and patient eligibility

About

The aim of this study is to assess the impact of a high-intensity aerobic training and resistance training on fatigue in prostate, head and neck and rectum cancer patients undergoing radiotherapy.

A three-arm randomized controlled trial will be conducted. Patients will be randomised into either a high-intensity aerobic training group or a resistance training group or a control group. Participants in the training groups will exercised for five to eight weeks. Exercise sessions will be take place 3 days per week under the supervision of an experienced therapist. Subjects will be assessed at baseline and post-intervention. The primary outcome will be fatigue measured using the FACIT-fatigue questionnaire. The secondary outcomes will be: functional capacity, quality of life, executive functions, sleep disturbances, somnolence syndrome, insomnia, depression symptoms.

Enrollment: 78 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria :

• a primary diagnosis of prostate cancer, head and neck cancer (oral cavity, pharynx, larynx, nasal cavity/sinuses, or salivary gland) or rectum cancer;
• age over 18 years;
• no distant metastases and/or disease progression;
• at least 25 scheduled radiation treatments (5 weeks);
• ability to read, write, and speak French.

Exclusion criteria :

• uncontrolled cardiac, hypertensive or pulmonary diseases,
• uncontrolled insulin-dependent diabetes mellitus,
• neuropsychiatric disorders or orthopaedic conditions that would impair exercise participation
• abnormal electrocardiogram.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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78 participants in 3 patient groups

High-intensity aerobic training group

Experimental group

Description:

High intensity interval training

Treatment:

Behavioral: High-intensity interval training

Resistance training group

Active Comparator group

Description:

Muscle strengthening

Treatment:

Behavioral: Resistance training

Control group

No Intervention group

Description:

Usual care