Effects of HIIT in Tolerance to Exercise of Individuals With HF and Coexisting COPD

Universidade Federal de Pernambuco

Status: Suspended

Conditions: Chronic Obstructive Pulmonary Disease; Heart Failure

Treatments: Other: Continuous aerobic training; Other: High-intensity interval training

Study type: Interventional

Funder types: Other

Identifiers

NCT04350541

07640919.4.0000.5208

Details and patient eligibility

About

INTRODUCTION: The complexity of the pathophysiology of heterogeneous diseases such as heart failure and obstructive pulmonary disease causes a different approach to these diseases or with a view as much as a better understanding of the same situations, with which the clinical profile of patients who are associated with an association is. It is known that regular physical training promotes progressive improvements in exercise tolerance, in the pulmonary ventilation / perfusion ratio and in respiratory function by strengthening. OBJECTIVE: To compare the effects of high-intensity interval training and continuous aerobic exercise, with peripheral endothelial function, brain natriuretic peptide levels, maximum exercise tolerance, distribution of lung volumes and quality of life of patients with obstructive pulmonary disease associated with heart failure. METHODS: This is a clinical, controlled, randomized and blinded trial. Peripheral endothelial function, tolerance to maximum and submaximal exercise, distribution of lung volumes, quality of life, presence of symptoms of depression and perception of clinical change will be evaluated. EXPECTED RESULTS: Incorporate into the care of these patients, new effective therapeutic approaches, of low cost and with greater technical and scientific evidence.

Enrollment: 40 estimated patients

Sex: All

Ages: 50 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sedentary individuals with Heart Failure of all etiologies;
• Diagnosed moderate and severe chronic obstructive pulmonary disease;
• Clinical stability;
• No change in the medication class within three months before the beginning of the research.

Exclusion criteria

• Unstable angina;
• Myocardial infarction;
• Previous cardiac surgery up to three months before the beginning of the study;
• Hemodynamic instability;
• Orthopedic and neurological diseases;
• Psychological and/or mental impairment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Interval training

Experimental group

Description:

Interval training will consist of 10 minutes of warm-up between 40-50% of the peak oxygen consumption (VO2peak), followed by four to six repetitions of three-minute intervals between 80-90% of VO2peak and three minutes between 40-50% VO2peak and finally, five minutes of cooling down between 30-40% of VO2peak.

Treatment:

Other: High-intensity interval training

Continuous training

Active Comparator group

Description:

The continuous aerobic training will consist of 10 minutes of warm-up with intensity between 40 and 50% of VO2peak, 20 minutes of conditioning between 60 and 70% of VO2peak and 5 minutes of cooling down between 30 and 40% of VO2peak.

Treatment:

Other: Continuous aerobic training