Effects of HIIT on Plasma Volume and Aerobic Capacity in Obese Adolescent Girls

High Institute of Sports and Physical Education of Kef

Status: Completed

Conditions: Hematologic Test

Treatments: Behavioral: High intensity interval training

Study type: Interventional

Funder types: Other

Identifiers

NCT07046520

HIIT-ADO-2025-TN

Details and patient eligibility

About

The goal of this clinical trial is to investigate the impact of high-intensity interval training (HIIT) program on body composition, hematological parameters, plasma volume variations (PVV), muscle damage markers, and aerobic capacity in overweight/obese adolescent girls. The main question it aims to answer is: Does HIIT reduce risk factors associated obesity diseases by modulating body composition and hematological parameters and increasing PVV? Researchers will compare HIIT (designed to the experimental group) to nontraining intervention (designed to the control group) to see if the training program works to enhance physiological health and reduce risk factors associated with obesity in this population. Participants in the experimental (HIIT group) group will: underwent HIIT at 90-105% maximal aerobic speed (MAS), three times a week.

Participants in control group will : not perform any physical training and maintain their usual daily activities.

Full description

Obesity during adolescence is linked to adverse changes in body composition, aerobic fitness, and blood health. High-intensity interval training (HIIT) is a promising strategy to improve these outcomes. However, its effects on hematological markers, plasma volume, and muscle damage in overweight/obese adolescent girls remain unclear. This study aimed to investigate the effects of HIIT on body composition, hematological parameters, plasma volume variations (PVV), muscle damage markers, and aerobic capacity in this population.Twenty-eight overweight/obese girls (16.21±0.92) were randomly assigned to a HIIT group (n=14) or control group (n=14). The 10-week HIIT protocol consisted of 4×6×15s running at 90-105% maximal aerobic speed (MAS) with 15s of active recovery at 50% MAS (3 sessions/week). Pre/post assessments included body composition, hematological markers, muscle damage markers, and aerobic fitness. Plasma volume was estimated post-intervention in both group.

Enrollment: 28 patients

Sex: Female

Ages: 15 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Females.
• Aged between 15 and 17 years.
• BMI greater than or equal to the 95th percentile for their age.

Exclusion criteria

• Pharmacological treatments or medical conditions that could interact with the protocol (e.g.,hypertension, diabetes, cardiac, orthopedic, neuromuscular, or neurological disorders).
• Hormone replacement therapy or therapies for obesity.
• Irregular menstrual cycle.
• Restrictive diet or use of dietary supplements or engagement in any structured physical training either currently or during the previous three months.
• Withdrawal of consent.
• Non-compliance with study procedures.
• Insufficient data for analysis.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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28 participants in 2 patient groups

High-intensity interval training group

Experimental group

Description:

High-intensity interval training group performed four series of 15-second runs at 90-105% of the maximal aerobic speed (MAS) interspersed with 15 seconds of active recovery at 5O% MAS.

Treatment:

Behavioral: High intensity interval training

Control group

No Intervention group

Description:

No training intervention was intended for the control group.