Effects of HMB Supplementation on Recovery Following ACL Surgery

Metabolic Technologies

Status: Completed

Conditions: ACL Injury

Treatments: Dietary Supplement: HMB; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02602561

MTI2015-CS02

Details and patient eligibility

About

The anterior cruciate ligament (ACL) is a primary stabilizer of the knee, and thus when ACL injury occurs participation in physical activity is compromised. Reconstructive surgery is often necessary to repair the damage which is then followed by a regimen of physical therapy in order to regain full activity. Nutritional intervention after the surgery could help the patient maintain muscle mass during recovery, thus allowing for a quicker return to normal activity.

Full description

Beta-hydroxy-beta-methylbutyrate (HMB) is a nutritional supplement shown to improve muscle mass with exercise, and also in muscle loss conditions caused by a decrease in physical activity. Participants will be recruited who will undergo reconstructive surgery for a complete ACL tear and will then enter a standard physical therapy program during a six week recovery period. Subjects will receive either HMB or a placebo supplement during the recovery period. Muscle mass will be measured two weeks prior to the surgery and again after the recovery period using an InBody 720 body composition analyzer. Additionally, the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire will be administered as a measure of recovery and activity level during the study.

Enrollment: 4 patients

Sex: All

Ages: 18 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Complete anterior cruciate ligament (ACL) tear
• Will benefit from ACL reconstructive surgery
• Are able to participate in the physical therapy program
• No previous major knee injuries or surgeries
• No health conditions affecting muscle mass

Exclusion criteria

• Incomplete ACL tear
• Have multiple or bilateral ligament tears
• Are unable to participate in the physical therapy program
• Have had previous major knee injuries or surgeries
• Have health conditions affecting muscle mass

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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4 participants in 2 patient groups, including a placebo group

HMB

Active Comparator group

Description:

3 g HMB/day

Treatment:

Dietary Supplement: HMB

Placebo

Placebo Comparator group

Description:

Placebo administered similar to the active comparator

Treatment:

Dietary Supplement: Placebo