Effects of Home-based Exercise in Parkinson's Disease

Mahidol University

Status: Unknown

Conditions: Parkinson Disease

Treatments: Other: Exercise

Study type: Observational

Funder types: Other

Identifiers

NCT04810897

MU-CIRB 2020/048.1902

Details and patient eligibility

About

Home-based exercise program focusing on axial rigidity could be used as an adjunct rehabilitation program to improve rotational movement, gait and functional movement associated with axial rigidity in individuals with PD.

Full description

Typically, individuals with PD revert to more primitive movement patterns, which lack many of the automatic postural adjustments and axial movements that accompany simple activities, such as supine to standing, getting up from sitting or turning over in bed. The present study is designed to allow patients and their relatives to perform exercises by themselves conveniently at home. The results were considered a vital component of a complex intervention and were played an integral part in the implementation process of exercises in functional performance. Furthermore, this study will prove sufficient high-quality evidence to investigate whether improvements in function due to exercise-based rehabilitation are associated with reducing axial rigidity in individuals with PD.

Currently, there is a lack of evidence for the effectiveness of home-based exercise programs in PD patients in Thailand. For the present study, we devised a home-based 10-week exercise program focusing on segmental rotation and task-specific movements for turning practice to determine effects on axial mobility and turning. The aimed of this study to examine the effects of a 10-week task specific home-based exercise program on turning kinematics, gait and stepping characteristics, the Functional Reach test (FRT), the Unified Parkinson's Disease Rating Scale (UPDRS), the Freezing of Gait questionnaire (FOG) and the Fall Efficacy Scale International (FES-I) in individuals with PD.

Enrollment: 20 estimated patients

Sex: All

Ages: 60 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

1. Inclusion Criteria;

   • Clinically diagnosed with PD stages 1.5 to 3 as assessed by the modified Hoehn and Yahr scale
   • The age groups between 50 and 75 years
   • Taking PD medication regularly for at least a month
   • No signs of wearing-off phenomenon
   • Able to walk independently without any assistive device and 6) able to follow commands and instructions

2. Exclusion Criteria;

   • Clinically diagnosed with dementia or other neurological or cardiopulmonary diseases
   • Musculoskeletal problems that could influence the test performance such as arthritis or severe leg pain
   • High blood pressure (more than 140/90 mmHg)
   • Haemodialysis
   • Visual problems that could not be adjusted with lenses or glasses
   • Taking medicine which affected to functional movement.

Trial design

20 participants in 1 patient group

Parkinson's disease

Description:

The neurologists will inform the individuals with PD that we are doing this research and we will attach the research advertisement at Movement Disorder Clinic, Division of Neurology, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand. Only individuals with PD who meet the inclusion and exclusion criteria will be invited to participate in the study. The researcher will inform participants about the purpose, procedure, and advantage of the study prior to participation in the study. Individuals with PD will be asked to sign an informed consent if they agree to participate in the study.

Treatment:

Other: Exercise