Effects of Home Exercise Intervention on Bone Density, Muscle Functions, QoL, and Curve Progression in Girls With AIS

The Chinese University of Hong Kong

Status: Completed

Conditions: Adolescent Idiopathic Scoliosis

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03157570

AISE_20170407

Details and patient eligibility

About

Studies with exercise intervention aimed to improve the bone health and muscle functions in patients with AIS were lacking. Evidence suggested that low bone mass and low muscle mass were associated with curve severity and occurrence of AIS. Weight-bearing exercise that aimed to improve musculoskeletal and metabolic health could enhance bone health and muscle mass, and could provide a feasible alternative conservative treatment to prevent curve progression as well as the quality of life in AIS girls. This is a pilot feasibility study for future large randomized controlled trial (RCT) aiming at determining the effects of home based exercise program on improving bone mineral density (BMD), muscle mass and functions, quality of life (QoL), and prevent curve progression in skeletally immature girls with adolescent idiopathic scoliosis (AIS).

Enrollment: 40 patients

Sex: Female

Ages: 11 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cobb Angle greater or equal to 15°
• Newly diagnosed at the Scoliosis Clinic without prior treatment
• Cleared for physical activity by doctor

Exclusion criteria

• Scoliosis with any known etiology such as congenital scoliosis, neuromuscular scoliosis, scoliosis of metabolic etiology, scoliosis with skeletal dysplasia, or
• Known endocrine and connective tissue abnormalities, or
• Known heart condition or other diseases that could affect the safety of exercise
• Eating disorders or GI malabsorption disorders or
• Currently taking medication that affects bone or muscle metabolism

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Exercise intervention group

Experimental group

Description:

The exercise group will participate in a 6-month home exercise along with demonstration videos. The exercise training program is an online 7-minute high-intensity interval training (HIIT) exercise through the integrated application of an exercise provision website and mobile Apps. The program will comprise of a broad range of exercises, applied at varying speeds and directions in order to increase heart rate, and to load a variety of muscle groups and skeletal regions in the upper and lower body. The exercise will be performed 5 days per week with the remaining 2 days as rest days.

Treatment:

Behavioral: Exercise

Control group

No Intervention group

Description:

The control group have no intervention and receives only standard care.