Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin

Cedars-Sinai Medical Center

Status: Completed

Conditions: Hookah Smoking

Treatments: Other: Hookah smoking

Study type: Interventional

Funder types: Other

Identifiers

NCT02147665

Pro00031150

Details and patient eligibility

About

This is a pilot study on acute effects of Hookah smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart rate variability suggesting - but not proving - sympathetic mediation. Here the investigators will directly measure the acute effects of Hookah smoking on sympathetic nerve activity with microneurography (intraneural microelectrodes) and quantify associated regional changes in vasomotor tone.

Enrollment: 42 patients

Sex: All

Ages: 18 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 39 years of age
• Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months
• Have not smoked cigarettes within the past 12 months

Exclusion criteria

• Exhaled carbon monoxide level greater than 10 ppm* as evidence of current or recent cigarette (excluded if smoked cigarette within 12 months) or Hookah smoking (excluded if smoked Hookah within past 72 hours)
• History of cardiopulmonary disease
• Use of any prescription medication with exception of oral contraceptive pills
• History of psychiatric illness
• History of neurologic disease
• BMI ≥ 35
• Evidence of any of the above by physical examination, ECG or echocardiogram
• Smoked cigarette in the past 12 months
• History of illicit drug use
• Pregnant
• Any other condition(s) deemed by the physician investigators that put subjects at risk for participating in the study

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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42 participants in 1 patient group

Hookah smoking

Experimental group

Description:

Healthy habitual Hookah smokers will undergo microneurography, myocardial contrast echocardiogram or venous occlusion plethysmography before and after Hookah smoking.

Treatment:

Other: Hookah smoking