Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function

Cedars-Sinai Medical Center

Status: Terminated

Conditions: Hookah Smoking

Treatments: Other: Hookah smoking

Study type: Interventional

Funder types: Other

Identifiers

NCT03616002

Pro00036547

Details and patient eligibility

About

The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.

Full description

The investigators will measure acute endothelial and vascular changes before and after a 30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and aortic pressure waveform measured by pulse tonometry.

Enrollment: 58 estimated patients

Sex: All

Ages: 18 to 29 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 29 years of age
• Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months
• Have not smoked cigarettes within the past 12 months

Exclusion criteria

• History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease
• Exhaled carbon monoxide level >10 ppm
• BP < 140/90 mmHg
• BMI <18.5 or > 30 kg•m2
• Resting heart rate > 100 beats/min
• Taking prescription medication
• History of illicit drug use
• Pregnant

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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58 participants in 1 patient group

Hookah smoking

Experimental group

Description:

Healthy habitual Hookah smokers will undergo brachial artery flow mediated dilation, reactive hyperemia peripheral arterial tonometry or pulse tonometry before and after Hookah smoking.

Treatment:

Other: Hookah smoking