Effects of Hydrogen Gas Inhalation on Adults of Various Ages

Wonju Severance Christian Hospital

Status: Completed

Conditions: Alzheimer Disease

Treatments: Other: H2 gas inhalation

Study type: Interventional

Funder types: Other

Identifiers

NCT05891938

EMB-2023-01

Details and patient eligibility

About

Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages.

Full description

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants including those dropped out (5%) were screened and enrolled. The selected participants were treated as a single group without randomization. Evaluated the association between total and differential white blood cell (WBC) counts and AD risk at individual levels after 4 weeks of H2 gas inhalation treatment. Furthermore, evaluation of dementia-related biomarkers such as beta-site APP cleaving enzyme 1 (BACE-1), amyloid beta (Aβ), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor A (VEGF-A), T-tau, monocyte chemotactic protein-1 (MCP-1), and inflammatory cytokines (interleukin-6).

Enrollment: 54 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion

• Age ranges 40-70 years
• Healthy participants
• Patients who are willing or able to follow the doctor's instructions
• Fully understand the purpose and procedure of this clinical trial

Exclusion Criteria

• Participants excluded those who have any disease
• Pregnant and lactating women

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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54 participants in 1 patient group

Single arm

Experimental group

Description:

Single group treatment

Treatment:

Other: H2 gas inhalation