Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients

Ege University

Status: Completed

Conditions: Xerostomia; Sjögren's Syndrome

Treatments: Drug: Hydroxychloroquine

Study type: Observational

Funder types: Other

Identifiers

NCT00873496

EAlpoz 1

Details and patient eligibility

About

Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to decreased salivary output. Hydroxychloroquine may inhibit cholinesterase activity in salivary glands via interference with antigen processing mechanism, and thus, the investigators' hypothesis was that salivary gland function may be improved if treated with hydroxychloroquine. The effects of hydroxychloroquine on the salivary flow rate, subjective and objective parameters of the patients were also assessed.

Enrollment: 30 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who were recently diagnosed with primary SS according to American-European criteria and who were scheduled for HCQ treatment in Ege University Faculty of Medicine, Department of Rheumatology

Exclusion criteria

• Sjögren patients consuming alcohol or tobacco

Trial design

30 participants in 1 patient group

Sjögren

Description:

Pre and post treatment establishment of salivary flow rate, objective and subjective clinical oral complications' severity of the patients using hydroxychloroquine

Treatment:

Drug: Hydroxychloroquine