Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol

DongGuk University

Status: Completed

Conditions: Anesthesia Recovery Period; Anesthesia, Intravenous

Treatments: Procedure: No rebreathing tube (Nothing); Procedure: Rebreathing tube

Study type: Interventional

Funder types: Other

Identifiers

NCT01531491

J In 2011-3

Details and patient eligibility

About

Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.

Enrollment: 30 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status (ASA PS) I-II
• Age 20 - 60 years male and female
• Elective schedule with minor surgery under general anesthesia

Exclusion criteria

• Body mass index (BMI) >= 30 (kg/m2)
• Patient with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history
• Patient with medication affecting on this study
• Patient with general anesthesia history within one month

Trial design

30 participants in 2 patient groups

Hypercapnia group

Experimental group

Description:

Respiratory rate will be 10/min and the rebreathing tube will be connected between the y-piece of corrugated tube and the tracheal tube to maintain the partial pressure of the end-tidal carbon dioxide at around 50 mmHg during emergence after propofol anesthesia.

Treatment:

Procedure: Rebreathing tube

Hypocapnia group

Experimental group

Description:

No rebreathing tube (Nothing) will be connected. Respiratory rate will be 10/min and the tidal volume will be modulated to maintain the partial pressure of the end-tidal carbon dioxide at around 30 mmHg during emergence after propofol anesthesia.

Treatment:

Procedure: No rebreathing tube (Nothing)