Effects of Hypoxia on Cognitive Performance (HYPCOG)

University of Castilla-La Mancha

Status: Completed

Conditions: Hypoxia

Treatments: Other: Hypoxia

Study type: Interventional

Funder types: Other

Identifiers

NCT06318312

HYP_MR_2024

Details and patient eligibility

About

The goal of this clinical trial is to determine the effects of different hypoxia exposures (FiO2 = 11%, 13%, 15%, and 21%) on cognitive performance in healthy adults. The main questions it aims to answer are:

• What is the best hypoxia exposure to improve reaction time, anticipation, attention and memory tasks?
• Which hypoxia exposure causes the greatest detriments in cognitive function?

Full description

Participants will completed four trials in a single-blinded crossover randomised control trial. In the first session, individuals familiarised with the different cognitive tests and hypoxic exposures. In the next four experimental trials (separated by 1 week), participants arrived at the laboratory and rested in a seated for 10 min. The vital signs (i.e., SpO2, HR, blood pressure) and Lake Louise Score were recorded prior to mask placed and start with in one of the four conditions: a) PLA/NOR, b) FiO2=15%, c) FiO2=13% or FiO2=11%. In this hypoxic condition the participant will spend a total of 45 min, of which 30 min was at rest, and the other 15 min was performing the cognitive tasks (i.e., memory test, go/no-go test, eriksen flanker test, anticipation task and reaction time test).

Enrollment: 26 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Physically active individuals ( >150 min/week moderate physical activity or >75 min/week vigorous physical activity)
• Non-smokers
• Individuals without serious and undiagnosed health problems

Exclusion criteria

• Pregnancy and/or breastfeeding
• Residing at an altitude of more than 1300 m
• Having been exposed to an altitude of more than 900 m in the last 8 months
• Having performed a study with hypoxia in the last 8 months
• Suffering from any of the following diseases/pathologies: diabetes, sleep apnoea, dyslexia, colour blindness, blurred vision, respiratory and/or neuromuscular diseases.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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26 participants in 4 patient groups, including a placebo group

11% FiO2

Experimental group

Description:

Hypoxic exposure: fraction of oxygen inspired (FiO2) = 11% (\~5100 m, \~16735 ft)

Treatment:

Other: Hypoxia

13% FiO2

Experimental group

Description:

Hypoxic exposure: fraction of oxygen inspired (FiO2) = 13% (\~3800 m, \~12470 ft)

Treatment:

Other: Hypoxia

15% FiO2

Experimental group

Description:

Hypoxic exposure: fraction of oxygen inspired (FiO2) = 15% (\~2750 m, \~9000 ft)

Treatment:

Other: Hypoxia

PLA / 21% FiO2

Placebo Comparator group

Description:

Hypoxic exposure / placebo condition: fraction of oxygen inspired (FiO2) = 21% (sea level)

Treatment:

Other: Hypoxia