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Effects of i-PRF on Non-surgical Periodontal Treatment

P

Pamukkale University

Status

Completed

Conditions

Platelet-Rich Fibrin

Treatments

Procedure: non surgical periodontal treatment

Study type

Observational

Funder types

Other

Identifiers

NCT05753631
22.02.2022/04

Details and patient eligibility

About

Injectable platelet-rich fibrin, a platelet concentrate in a liquid formulation, has been developed to provide clinicians with ease of use alone or in combination with various biomaterials. The low-speed centrifugation method provides a significant advantage to the regeneration process with richer platelets, leukocytes, and growth factors. It also contributes to the wound-healing process by increasing vascularization. It is expected that the application of injectable platelet-rich fibrin into the gingival pocket following subgingival curettage in periodontitis patients will positively affect the results of non-surgical periodontal treatment. For this reason, in this study it was aimed to investigate the early effects of injectable PRF applied into the pocket for root surface biomodification following subgingival curettage in periodontal pockets of 6 mm and above, by evaluating both clinical parameters and inflammatory and healing markers in the gingival groove fluid

Full description

The study was planned as a randomized controlled split-mouth clinical trial. A split-mouth design was used to better assess how the same host responded to two different treatment modalities. Two quadrants with contralateral deep periodontal pockets in each participant were selected and randomly divided into test and control groups.

Test group: Injectable platelet-rich fibrin application into the selected deep periodontal pocket after scaling and root planning (SRP) procedure.

Control group: No agent was applied to the periodontal pocket after scaling and root planning.

On the first visit, clinical periodontal measurements were taken before the SRP procedure. Plague index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were used as clinical periodontal parameters.

After 1 week, the patients were called again for the SRP procedure. Injectable PRF obtained from the intravenous blood sample taken from the antecubital vein of the patients was injected into the deepened periodontal pocket subgingivally after the SRP procedure in the test group. Clinical periodontal measurements at 1 month and 3 months after SRP were repeated.

Gingival crevicular fluid (GCF) samples were taken from selected teeth before the SRP procedure. On the 3rd and 7th day after the SRP, GCF samples were taken again from the same region.

GCF vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-α), and interleukin (IL)-10 levels were evaluated by using the ELISA method and compared between groups.

Enrollment

24 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients with stage 3 grade B periodontitis

Exclusion criteria

  • patients with systemic disease
  • pregnant and breastfeeding
  • acute or chronic infection in the past 6 months
  • Use of systemic antibiotic therapy in the past 6 months
  • use of drugs that can affect periodontal health
  • receiving hormone therapy
  • smokers
  • teeth with endodontic lesions
  • Teeth with class 2 and 3 mobility

Trial design

24 participants in 2 patient groups

SRP+i-PRF (test)
Description:
Injectable platelet-rich fibrin (i-PRF) application into the selected deep periodontal pocket after scaling and root planning (SRP) procedure.
Treatment:
Procedure: non surgical periodontal treatment
SRP (Control)
Description:
No agent was applied to the periodontal pocket after scaling and root planning.
Treatment:
Procedure: non surgical periodontal treatment

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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