Effects of Immunonutrition in Patients With Pneumonia
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About
The project is a randomized controlled trial taking place in the North Zealand hospital in the city Hilleroed, Denmark.
The aim is to investigate the potential beneficial effects of immunonutrition containing fish oil, arginine and RNA, on the acute immune response in patients with pneumonia.
Full description
Immunonutrition has a well-documented beneficial effect on surgical patients by strengthening the immune system and reducing the following: inflammation, the number of infections as well as hospitalization time. A study in operated patients demonstrated the benefit of immunonutrition by reducing unwanted inflammation, measured by the pro-inflammatory signalling protein, interleukin-6. The same study saw a smaller decrease in immune function (measured as the level of phagocytosis) in the group receiving immunonutrition than in the control group. This project will investigate whether similar effects can be detected in patients with pneumonia.
The project is being carried out in a collaboration between the University of Copenhagen, The main hospital of Copenhagen (Rigshospitalet) and North Zealand Hospital. The project is a randomized clinical intervention study, which spans 10 days. Participants are allocated to the intervention group or the control group. The project is being carried out at the North Zealand hospital, at the Department of Pulmonary- and Infectious Diseases.
The intervention group receives the department's standard treatment (Standard Of Care) + immunonutrition, while the control group receives the hospital department's standard treatment (Standard Of Care). On a daily basis, the patient's clinical condition and the activity of the immune system is measured for the purpose of determine whether there is an effect of immunonutrition.
Enrollment
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Volunteers
Inclusion criteria
- Authorized individuals diagnosed with pneumonia who speak and write in danish
Exclusion criteria
- individuals with Immunodeficiency
- individuals with another primary diagnose
- individuals with an allergy against product ingredients
- individuals with dementia
- individuals with dysphagia
- individuals with cancer in treatment
- individuals with Chronic Obstructive Pulmonary Disease on continuing steroid treatment or home administered oxygen treatment
Trial design
Primary purpose
Allocation
Interventional model
Masking
40 participants in 2 patient groups
Trial contacts and locations
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Central trial contact
Anna G Eilersen, student; Jens R Andersen, Assoc. Prof.
Data sourced from clinicaltrials.gov
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