Effects of Increased CF-LVAD Pump Speed During Sustained Submaximal Exercise

Rigshospitalet

Status: Completed

Conditions: Heart Failure

Treatments: Other: CF-LVAD pump speed baseline.; Other: CF-LVAD pump speed increased.

Study type: Interventional

Funder types: Other

Identifiers

NCT02335684

H-1-2013-103

Details and patient eligibility

About

This randomized trial has been designed to study if it is possible to enhance work capacity during submaximal efforts in heart failure patients supported with continuous-flow left ventricular assist devices (CF-LVAD).

The hypothesis is that exercise tolerability during low to moderate workloads in CF-LVAD patients can be increased when pump speed is increased soon after the onset of exercise.

Full description

To test the hypothesis described above the investigators will study submaximal exercise tests below anaerobic threshold in patients supported with CF-LVADs.Each patient will perform two tests- one with baseline CF-LVAD pump speed and the other with incrementally increased pump speed.

Enrollment: 31 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ischemic and non-ischemic cardiomyopathy patients with CF-LVADs,signed informed consent.

Exclusion criteria

• Unstable patients, CF-LVAD implantation less than three months ago.

Trial design

31 participants in 1 patient group

CF-LVAD patients.

Experimental group

Description:

Patients are compared with themselves during submaximal exercise testing with baseline pump speed vs. submaximal exercise testing with increased pump speed.

Treatment:

Other: CF-LVAD pump speed baseline.

Other: CF-LVAD pump speed increased.