Effects of Intensive Statin Treatment on Left Ventricular Function

Shenyang Northern Hospital

Status and phase: Unknown; Phase 4

Conditions: Acute Anterior Myocardial Infarction

Treatments: Drug: intensive group; Drug: standard group

Study type: Interventional

Funder types: Other

Identifiers

NCT01936103

NH-20120404

Details and patient eligibility

About

First acute anterior myocardial infarction in patients with primary PCI preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left ventricular function , reduce major adverse cardiovascular events .

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ≥ 18 years of age
2. the first time clinical diagnosis of acute anterior myocardial infarction , the time of onset ≤ 12 hours ,intends underwent emergency PCI
3. informed consent

Exclusion criteria

1. Taking , or the need for long-term use of statins is greater than the initial dose
2. treated with PCI again within a mouth
3. active liver disease or liver dysfunction
4. the diagnosis of myopathy
5. severe renal insufficiency ( serum creatinine > 178umol / L )
6. Statin drug allergy or had a serious adverse reaction
7. severe aortic stenosis or mitral stenosis , hypertrophic obstructive cardiomyopathy , pericardial disease
8. pregnancy
9. malignancy or any other end-stage diseases result in a life expectancy of < 6 months
10. be participating in other clinical studies
11. not suitable for inclusion of the other cases
12. not treated with PCI

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 2 patient groups

standard group

Active Comparator group

Description:

patients in this group received standard statin treatment： Atorvastatin statins 20mg / night .

Treatment:

Drug: standard group

intensive group

Experimental group

Description:

patients in this group received intensive statin treatment： Admission atorvastatin statins the 80mg, after surgery，atorvastatin 40mg / night，and until 30 days after the operation , and thereafter 20mg / night .

Treatment:

Drug: intensive group